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Liraglutide did not significantly inhibit pyroptosis in BV2 cells in vitro, although its protective properties in a mouse model of EAE appear to be related to AMPK regulation, autophagy and inhibition of pyroptosis [265]

Mechanism difference Semaglutide (GLP-1 agonist): appetite regulation, satiety, improved glycemic control (New England Journal of Medicine) Tirzepatide (GLP-1/GIP agonist): broader incretin effects, robust appetite/weight effects (New England Journal of Medicine) AOD-9604: targeted fat-metabolism signaling

71 NAC also appears to have a balancing effect on neurotransmitter dysregulation, in particular glutamate homeostasis

The Journal of Steroid Biochemistry and Molecular Biology